HOW DOES
LENVIMA WORK?

HOW DOES LENVIMA WORK?

It is believed that LENVIMA works by interfering with processes tumors rely upon to grow and live in the body.

There are 2 places in the body where it does this:

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Cells
LENVIMA is believed to interfere with the way cells attempt to survive and multiply.
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Blood vessels
LENVIMA is also thought to impair some of the activities blood vessels need to grow. Blood vessels support the tumor’s survival and growth.

LENVIMA also affects healthy cells and, as a result, causes serious side effects.

LENVIMA IS PROVEN EFFECTIVE

LENVIMA was studied in a clinical trial of 954 patients with HCC who were not able to have surgery. The number of patients who were treated with LENVIMA was 478, and the number of patients treated with sorafenib was 476. In this trial, patients were randomly assigned to receive either LENVIMA or sorafenib. The results showed that treatment with LENVIMA was noninferior (not unacceptably worse) in comparison to sorafenib with respect to overall survival.
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Patients treated with LENVIMA lived for a median of 13.6 months, and the patients treated with sorafenib lived for a median of 12.3 months. The median time is halfway between the shortest and longest times that patients lived. Compared to the median time, half of the patients lived longer, and half of the patients lived for a shorter time.
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Patients treated with LENVIMA lived without their cancer getting worse twice as long as those treated with sorafenib — a median of 7.3 months compared with a median of 3.6 months for sorafenib.

A median is the middle number in a list of numbers arranged from lowest to highest.
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Almost 3.5 times as many patients treated with LENVIMA (41%) had their tumors shrink compared with patients treated with sorafenib (12%).

Ten patients in the LENVIMA arm (2.1%) vs four patients in the sorafenib arm (0.8%) showed no signs of disease, and 184 patients in the LENVIMA arm (38.5%) vs 55 patients in the sorafenib arm (11.6%) showed some signs of disease.


This trial proved that LENVIMA as the first treatment may benefit some patients with HCC where surgery is not an option.

RELATED CONTENT:
What is
LENVIMA?
Before you
take
LENVIMA
Taking
LENVIMA






Capsules not actual size
Managing
my treatment
side effects

What is LENVIMA?

It is not known if LENVIMA is safe and effective in children.

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What is LENVIMA?

  • LENVIMA is used by itself as the first treatment for a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed by surgery

It is not known if LENVIMA is safe and effective in children.

Important Safety Information

LENVIMA may cause serious side effects, including:

  • high blood pressure (hypertension): High blood pressure is a common side effect of LENVIMA and can be serious. Your blood pressure should be well controlled before you start taking LENVIMA. Your healthcare provider should check your blood pressure regularly during treatment with LENVIMA. If you develop blood pressure problems, your healthcare provider may prescribe medicine to treat your high blood pressure
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